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The ​B-cells and Antibodies community is comprised of individuals from different Institutions worldwide and includes the following members:​​

Dr Babak Javid

Co-Chair

Dr. Babak Javid is a physician-scientist and tenured Principal Investigator at the Tsinghua University School of Medicine. He went to medical school at the University of Cambridge, and following residency training in London, returned to Cambridge as an MRC training fellow for his PhD studies in immunobiology under Paul Lehner. After completing his training in infectious diseases, he went to Boston to learn mycobacterial genetics with Eric Rubin at the Harvard Chan School of Public Health as an MRC Clinician Scientist Fellow. He moved to Tsinghua in 2011 to set up his independent group. The Javid lab has an interest in human humoral immunity to tuberculosis, regulation of adaptive mycobacterial gene translation, and molecular mechanisms of antibiotic tolerance. Dr. Babak Javid is an Investigator of the Wellcome Trust.

Dr Simone Joosten

Co-Chair

Dr. Simone A Joosten is an Ass Prof at the Leiden University Medical Center,The Netherlands. Having a biomedical background with a specialization in immunology, my main interest is to understand the human immune system in health and disease. Over the last decade my group has been working on host immunity towards tuberculosis (TB). TB biomarkers are one of the key subjects we have been working on, including bioprofiling of clinical samples. In addition, we have been interested in cellular immunity towards Mycobacterium tuberculosis (Mtb). My group aims to unravel the pathophysiological role of cellular immune responses in the combat against Mtb. We focus in particular on HLA-E restricted CD8+T-cells, B-cells and more recently also monocyte subsets. We aim to combine clinical data and samples with functional immunological characterization of the responses.


Dr Galit Alter

Member

Dr. Galit Alter is a Professor of Medicine at the Ragon Institute of MGH, MIT and Harvard. Her researched is focused on the development of systems biology tools to define the correlates of humoral immunity against infectious diseases. Her tools are poised to profile the pathogen-specific humoral immune response at unprecedented depths, unlocking often unexpected roles of antibodies in the control and clearance of pathogens. Her work has led to the development of novel diagnostics to monitor infections, diseases, and vaccines, and now promises to accelerate the development and evaluation of novel classes of therapeutics and vaccines able to deploy the activity of the innate immune system to fight disease.


Dr John Chan

Member

Dr. John Chan received his training in Infectious Diseases at the Albert Einstein College of Medicine, where he is currently Professor of Medicine and Microbiology & Immunology. His laboratory studies the interaction between the host and Mycobacterium tuberculosis to characterize the lung immune response to the tubercle bacillus, and to decipher the mechanisms by which this pathogen evades host defense to enter a latent state and to later reactivate. The ultimate goal is to use the knowledge gained from the studies to develop effective anti-tuberculosis interventions. A component of his research program is to examine how B cells and immunoglobulins regulate the host response to M. tuberculosis in various phases of infection.


Dr Sarah Fortune

Member

Dr. Sarah Fortune is the John LaPorte Given Professor of Immunology and Infectious Diseases at the Harvard TH Chan School of Public Health and Director of the TB Research Program at the Ragon Institute of MGH, Harvard and MIT. She received a Bachelor of Science (B.S.) in biology from Yale University and an MD from Columbia University’s College of Physicians and Surgeons. She completed her residency in Internal Medicine and fellowship in Infectious Diseases at the Brigham and Women’s Hospital and Massachusetts General Hospital.

Her lab currently seeks to define bacterial determinants of the variability in clinical outcomes of tuberculosis. Areas of interest include mechanisms and rates of genetic and epigenetic diversification, and identification of mechanisms by which the bacterium generates high frequency diversity. Her group approaches these questions through a combination of bacterial genetic approaches, microfluidic and high density live cell imaging with high throughout methodologies such as comprehensive proteomics and whole genome sequencing. Dr. Fortune is supported by awards from the Burroughs Wellcome Foundation, NIAID, the Bill and Melinda Gates Foundation, and Aeras.


Dr Steve Porcelli

Member

Dr. Steven Porcelli is Professor and Chair in the Department of Microbiology and Immunology at the Albert Einstein College of Medicine in Bronx, New York, USA. He received his undergraduate degree from Columbia University in 1979, and an MD degree from Yale University in 1984. For the past 25 years, his laboratory has studied T cell mediated immunity in infection, autoimmunity and cancer. Studies on host immune evasion pathways in Mycobacterium tuberculosis infection are an area of long-term and current interest for his laboratory. Discovery of target antigens for inducing effective immune protection against tuberculosis and assessment of new live attenuated vaccine strains are among the topics being pursued by his research group.


Members

Dr Jacqueline Achkar

Dr Bryan Charleston

Dr Yuen-hsiu Chien

Dr Simon Draper

Dr Richard Frothingham

Dr Bill Jacobs

Dr Rasmus Morensen