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Human T cells play a central role in the human response to tuberculosis and in efforts to develop better vaccines. For decades, it was thought that T cells only that recognize antigens in the context of a diverse array of presentation molecules such that an epitope could be considered private, or restricted to each patient or human donor. Therefore, broad detection or alteration of T cell responses to one kind of antigen in all humans was viewed as technologically impossible. Over the past decade “Donor Unrestricted T cells” (DURT) that recognize their antigens through highly conserved molecules that are present among all humans have been discovered. The CTVD DURT research community seeks to harness these donor unrestricted T cell responses to MR1, CD1 and HLA-E proteins for improved vaccines against TB.

The DURT research community is comprised of individuals from different Institutions worldwide and includes the following members:​​

Tom Ottenhoff Co-chair
Chetan Seshadri Co-chair
John Altman Member
Erin Adams Member
Dan Hoft Member
Mitch Kronenberg Member
Dave Lewinsohn   Member
Branch Moody Member
Louis Picker Member
Jonah Sacha Member
Stenger Member
Treiner Member
Ildiko Van Rhijn Member​​​