​​​​Scientific Publications

Reviews

• Status of vaccine research and development of vaccines for tuberculosis
  Evans TG, Schrager L, Thole J.
  Vaccine. June 2016
  
• Vaccination against tuberculosis with whole cell mycobacterial vaccines
  Scriba TJ, Kaufmann SHE, Lambert PH, Sanicas M, Martin C, Neyrolles O.
  The Journal of Infectious Disease May 2016
  
• Mycobacterium tuberculosis infection and vaccine development
  Tang J, Yam WC, Chen Z.
  Tuberculosis May 2016​
  
• Tuberculosis vaccines and prevention of infection
  Hawn TR, Day TA, Scriba TJ, Hatherill M, Hanekom WA, Evans TG, Churchyard GJ, Kublin JG, Bekker LG, Self SG.
  Microbiol Mol Biol Rev. Dec 2014
  
• Side-by-side comparison of T cell reactivity to Mycobacterium tuberculosis antigens in diverse populations
  Carpenter C, Sidney J, Kolla R, Nayak K, Tomiyama H, Tomiyama C, et al.
  Tuberculosis (Edinb). 2015 Aug​
  
• Tuberculosis vaccines: Time for a global strategy
  Stefan H. E. Kaufmann, Thomas G. Evans, Willem A. Hanekom
  Science Translational Medicine 25 Feb 2015
  
• Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool
  Christopher L. Karp, Christopher B. Wilson, Lynda M. Stuart
  Immunological Reviews 2015
  
• Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?
  Tom H. M. Ottenhoff, Stefan H. E. Kaufmann
  PLoS Pathogens 2012
  
• Tuberculosis vaccines: beyond Bacille Calmette –Guerin
  Helen McShane
  Phil Trans R Soc 2011
  

Clinical Trials

• Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial
  Birahim Pierre Ndiaye, Friedrich Thienemann, Martin Ota, et al. FWACP for the MVA85A 030 trial investigators
  The Lancet Respiratory Medicine 2015
  
• Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial.
  Spertini F, Audran R, Chakour R, Karoui O, Steiner-Monard V, Thierry AC, Mayor CE, Rettby N, Jaton K, Vallotton L, Lazor-Blanchet C, Doce J, Puentes E, Marinova D, Aguilo N, Martin C​
  Lancet Respiratory Med. Dec 2015​

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Learning About Protective Immunity

• Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.
  Kaushal D, Foreman TW, Gautam US
  ​Nature Communications. 13 Oct 2015 ​

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• Drug-resistant TB: deadly, costly and in need of a vaccine
  Manjelievskaia J, Erck D, Piracha S, Schrager L
  Trans Royal Society of Trop Med and Hygiene March 2016
  
• M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens
  Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst, JD, Gagneux S.
  Cell Host and Microbe 2015​
  
• TB vaccines; promoting rapid and durable protection in the lung.
  Andersen P, Urdahl KB.
  Curr Opin Immunol Jun 2015
  
• The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis.
  Henao-Tamayo M, Shanley CA, Verma D, Zilavy A, Stapleton MC, Furney SK, Podell B, Orme IM.
  PLoS ONE Sept 2015​
  
• Evaluation of the pharmacokinetic interaction between repeated doses of rifapentine or rifampin and a single dose of bedaquiline in healthy adult subjects
  Helen Winter, Erica Egizi, Stephen Murray, et al.
  Antimicrob Agents Chemother 2015
  
• Latent tuberculosis infection in rural China: baseline results of a population-based, multicentre, prospective cohort study
  Lei Gao, Wei Lu, Liqiong Bai, et al. for the LATENTTB-NSTM study team
  The Lancet Infectious Diseases 2015
  

Pipeline Reports

• HIV, HCV, and TB: Drugs, Diagnostics, Vaccines, Preventive Technologies, Research Toward a Cure, and Immune-Based and Gene Therapies in Development